Abstract Background: Major infectious disease outbreaks are a constant threat to human health. Clinical research responses to outbreaks generate evidence to improve outcomes and outbreak control. Experiences from previous epidemics have identified multiple challenges to undertaking timely clinical research […]
In Depth | Covid-19 Opens in modal lightboxi A World Health Organization trial of COVID-19 treatments has been slow to recruit patients, such as this one in Spain. PHOTO: PAU BARRENA/AFP/GETTY IMAGES Viewable Image – a world health organization […]
Click here to view original web page at U.K. megatrial outshines other drug studies
Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on lopinavir-ritonavir, 29 June 2020 In March 2020, the RECOVERY trial was established as a randomised clinical trial to test a range of potential treatments […]
A World Health Organization–led global trial of treatments for COVID-19 was slow to enroll coronavirus-infected people, like this one in a Spanish intensive care unit, whereas a large trial in the United Kingdom quickly produced results for three treatments. […]
Objectives The coronavirus disease 2019 (COVID-19) pandemic has prompted many initiatives to identify safe and efficacious treatments, yet little is known regarding where early efforts have focused. We aimed to characterise registered clinical trials assessing drugs or plasma treatments […]
After a review of the findings of Cao et al. (published in the Journal online on March 18), 1 many clinicians are abandoning the use of lopinavir–ritonavir for the treatment of Covid-19. We consider this action to be premature. […]
Click here to view original web page at A Trial of Lopinavir–Ritonavir in Covid-19
The global outbreak of coronavirus disease 2019 (COVID-19) has seen a deluge of clinical studies, with hundreds registered on clinicaltrials.gov . But a palpable sense of urgency and a lingering concern that “in critical situations, large randomized controlled trials […]
Click here to view original web page at Against pandemic research exceptionalism
Open Orphan PLC (LON:ORPH ) Chief Executive Officer Cathal Friel caught up with DirectorsTalk for an exclusive interview to discuss the world’s first human coronavirus challenge study model. Q1: We’ve just seen that you’ve begun the development of the world’s first commercial human coronavirus challenge study model. What can […]
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