SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease

We determined the antigen binding activity of convalescent plasma units from 47 individuals with a history of non-severe COVID-19 using three clinical diagnostic serology assays (Beckman, DiaSorin, and Roche) with different SARS-CoV-2 targets. We compared these results with functional neutralization activity using a fluorescent reporter strain of SARS-CoV-2 in a microwell assay. This revealed positive correlations of varying strength (Spearman r = 0.37-0.52) between binding and neutralization. Donors age 48-75 had the highest neutralization activity. Units in the highest tertile of binding activity for each assay were enriched (75-82%) for those with the highest levels of neutralization.,Read More

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

To the Editor: A recent article suggested the rapid decay of anti–SARS-CoV-2 IgG in early infection, 1 but the rate was not described in detail. We evaluated persons who had recovered from Covid-19 and referred themselves to our institution […]

Click here to view original web page at Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection

Abstract Background Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of SARS-CoV-2-specific neutralizing antibodies (NAbs) in COVID-19 patients. Methods Blood samples (n=173) […]

Click here to view original web page at Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection

How seroprevalence is helping us in the fight against COVID-19

Coloured transmission electron micrograph (TEM) of a SARS-CoV-2 coronavirus particle isolated from a UK case of the disease Covid-19. PHE’s Head of immunisation Dr Mary Ramsay describes how testing blood samples is helping us gather crucial data on the […]

Click here to view original web page at How seroprevalence is helping us in the fight against COVID-19

Chinese study: Antibodies in COVID-19 patients fade quickly

A new study from China showed that antibodies faded quickly in both asymptomatic and symptomatic COVID-19 patients during convalescence, raising questions about whether the illness leads to any lasting immunity to the virus afterward. The study, which focused on […]

Click here to view original web page at Chinese study: Antibodies in COVID-19 patients fade quickly

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

COVID-19 is an ongoing global crisis in which the development of effective vaccines and therapeutics will depend critically on understanding the natural immunity to the virus, including the role of SARS-CoV-2-specific T cells. We have conducted a study of […]

Click here to view original web page at Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

In December 2019 an outbreak of coronavirus disease (COVID-19) emerged in Wuhan, China. The causative agent was subsequently identified and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which rapidly spread worldwide causing a pandemic. Currently there are no […]

Click here to view original web page at Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge

Coronavirus: Study suggests COVID-19 immunity could last just six months

There is limited research on how long coronavirus antibodies last A person could be re-infected with coronavirus in six months, new research suggests, in a blow to the push for “immunity passports” as evidence of recovery from the illness. […]

Click here to view original web page at Coronavirus: Study suggests COVID-19 immunity could last just six months