The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

There is an urgent need for effective countermeasures against the current emergence and accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Induction of herd immunity by mass vaccination has been a […]

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How seroprevalence is helping us in the fight against COVID-19

Coloured transmission electron micrograph (TEM) of a SARS-CoV-2 coronavirus particle isolated from a UK case of the disease Covid-19. PHE’s Head of immunisation Dr Mary Ramsay describes how testing blood samples is helping us gather crucial data on the […]

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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Abstract Developing therapeutics against SARS-CoV-2 could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein, but also across the full Spike (S) protein. We isolated and characterized monoclonal […]

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IgA dominates the early neutralizing antibody response to SARS-CoV-2

A major dogma in immunology has it that the IgM antibody response precedes secondary memory responses built on the production of IgG, IgA and, occasionaly, IgE. Here, we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting […]

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Stockholm Won’t Reach Herd Immunity In May, Sweden’s Chief Epidemiologist Says

Sweden’s controversial approach to fighting the coronavirus pandemic has so far failed to produce the expected results, and there are calls within the country for the government to change its strategy. “We have a very vivid political debate,” Karin […]

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Only 4.4% of French population infected by coronavirus – Pasteur institute

PARIS (Reuters) – A study led by the Pasteur Institute says a mere 4.4% of the French population – or 2.8 million people – have been infected by the novel coronavirus, much higher than the official count of cases […]

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Cytokine storm intervention in the early stages of COVID-19 pneumonia.

Abstract Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients who are critically ill with SARS-CoV2-induced pneumonia. In a retrospective study of 41 patients with COVID-19, most patients […]

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The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses

1 Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States 2 Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States 3 Department […]

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What Is a Cytokine Storm?

As Covid-19 cases fill the hospitals, among the sickest and most likely to die are those whose bodies react in a signature, catastrophic way. Immune cells flood and attack the lungs they should be protecting. Blood vessels leak; the blood itself clots. Blood pressure plummets and organs start to […]

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