Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).

Abstract PURPOSE: Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 […]

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Comparative severity of influenza A and B infections in hospitalized children

Given influenza A viruses vs B viruses are conventionally considered to result in more severe illnesses, but the clinical severity of A and B infections in hospitalized children has been compared in few studies with long observation periods, and therefore, researchers assessed the clinical presentation, results as well as […]

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Acquisition of Avian-Origin PB1 Facilitates Viral RNA Synthesis by the 2009 Pandemic H1N1 Virus Polymerase.

Abstract The constant crosstalk between the large avian reservoir of influenza A viruses (IAV) and its mammalian hosts drives viral evolution and facilitates their host switching. Direct adaptation of an avian strain to human or reassortment between avian-origin gene segments with that of human strains are the two mechanisms […]

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Influenza A Virus Antibodies with Antibody-Dependent Cellular Cytotoxicity Function.

Abstract Influenza causes millions of cases of hospitalizations annually and remains a public health concern on a global scale. Vaccines are developed and have proven to be the most effective countermeasures against influenza infection. Their efficacy has been largely evaluated by hemagglutinin inhibition (HI) titers exhibited by vaccine-induced neutralizing […]

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Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases.

Abstract Abundant evidence points to a critical role for antibodies in protection and pathology across infectious diseases. While the antibody variable domain facilitates antibody binding and the blockade of infection, the constant domain (Fc) mediates cross-talk with the innate immune system. The biological activity of the Fc region is […]

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Structure of key pneumonia virus enzyme uncovered

Scientists have used cryo-electron microscopy to clarify the structure of one of the key components of RSV and HMPV, which could lead to new therapies for the viruses. Scientists have found a potential new route to disabling respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) after elucidating the structure […]

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New Elsevier report charts global trends in HIV/AIDS research

Download the report HIV/AIDS research insights: impacts, trends, opportunities at the end of this story. A new report gives a comprehensive overview of the AIDS/HIV research landscape, including the most active nations and institutions and trends in protein research that reflect developments in drug targets. Bamini Jayabalasingham, PhD In […]

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