Full length article OUTBREAK of novel corona virus disease (COVID-19): Antecedence and aftermath

Highlights • Life cycle of SARS-CoV-2 in host cell have been demonstrated. • CT scan and RT-PCR are very helpful in diagnosis of COVID-19 infection. • Antiviral, antimalarial, antimicrobial and ROCK inhibitors were found very effective. • Dietary supplements […]

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The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies

There is an urgent need for effective countermeasures against the current emergence and accelerating expansion of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Induction of herd immunity by mass vaccination has been a […]

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Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

Abstract In vitro antibody selection against pathogens from naive combinatorial libraries can yield various classes of antigen-specific binders that are distinct from those evolved from natural infection. Also, rapid neutralizing antibody discovery can be made possible by a strategy […]

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Lack of antibody-mediated cross-protection between SARS-CoV-2 and SARS-CoV infections

Abstract Background The novel coronavirus (SARS-CoV-2) shares approximately 80% whole genome sequence identity and 66% spike (S) protein identity with that of SARS-CoV. The cross-neutralization between these viruses is currently not well-defined. Methods Here, by using the live SARS-CoV-2 […]

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Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus

SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by TMPRRS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys […]

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Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial – The Lancet

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Chasing the origin of SARS-CoV-2 in Canada’s COVID-19 cases: A genomics study

The emergence and global spread of SARS-CoV-2 has had profound social and economic consequences and has shed light on the importance of continued and additional investment in global health and infectious disease surveillance. Identifying changes in viral genomes provides […]

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The Digital Migration: Lessons About Open Science Arising from the COVID19 Crisis

This blog post was written Dylan Roskams-Edris, Open Science Alliance Officer, Tanenbaum Open Science Institute, The Neuro. This piece resulted from an ongoing discussion with members of the Canadian open science community, in particular Estrid Jakobsen, Elizabeth DuPre, Zoha […]

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