Pixatimod (PG545), a clinical-stage heparan sulfate mimetic, is a potent inhibitor of the SARS-CoV-2 virus

A major global effort is currently ongoing to search for therapeutics and vaccines to treat or prevent infection by the SARS-CoV-2 virus. Repurposing existing entities is one attractive approach. The heparan sulfate mimetic pixatimod is a clinical-stage synthetic sulfated […]

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A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

Abstract Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether hydroxychloroquine can prevent symptomatic infection after SARS-CoV-2 exposure is […]

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Coronavirus: Malaria drug hydroxychloroquine ‘does not save lives’

Hydroxychloroquine received global attention after being taken by Donald Trump A malaria drug that has been tested as a treatment for coronavirus does not save lives, one of the world’s largest trials shows. Hydroxychloroquine received global attention after being […]

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Controversy over data in hydroxychloroquine COVID-19 study grows

The editors of The Lancet yesterday issued a statement acknowledging the criticism of a recent study that concluded that the antimalaria drugs hydroxychloroquine and chloroquine did not benefit COVID-19 patients and were associated with higher risk of death and […]

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Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery

Colorized scanning electron micrograph of an apoptotic cell (pink) heavily infected with SARS-COV-2 virus particles (green), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. What The investigational antiviral remdesivir […]

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Remdesivir for the Treatment of Covid-19 — Preliminary Report

Abstract Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious. We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 […]

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A ‘triumph of hope over facts’: The rise and fall of hydroxychloroquine for COVID-19

The rise and fall of chloroquine and hydroxychloroquine as “game-changing” treatments for COVID-19 should come as no surprise to experts who have paid attention to the history of these drugs, according to findings published in The FASEB Journal . […]

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Hydroxychloroquine: Trump’s Taking It, Now We’re Trialling It, And Four Other Things You Need To Know About Covid-19

Frontline workers will be able to take part in a trial of the anti-malaria drug in the UK. Here’s the latest.

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