Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus

SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface receptor ACE2 and subsequent priming by TMPRRS2 allowing membrane fusion. Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that ACE2-EVs are efficient decoys […]

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In vivo structural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs

SARS-CoV-2 is an RNA virus of the Coronaviridae family that is the causal pathogen of the ongoing Coronavirus Disease 2019 pandemic. There are currently no antiviral drugs or vaccines to treat COVID-19, and the failure to identify effective interventions […]

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U.S. Will Pay $1.6 Billion to Novavax for Coronavirus Vaccine

Andrew Caballero-Reynolds/Agence France-Presse — Getty Images The federal government will pay the vaccine maker Novavax $1.6 billion to expedite the development of 100 million doses of a coronavirus vaccine by the beginning of next year, the company said on […]

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The Importance of Advancing SARS-CoV-2 Vaccines in Children

Abstract While the role of children in the chain of transmission of SARS-CoV-2 remains to be fully defined, they likely play an important role based on our knowledge of other respiratory viruses. Children are more likely to be asymptomatic […]

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Operation Warp Speed’s opaque choices of COVID-19 vaccines draw Senate scrutiny

During a hearing on COVID-19 vaccines, Francis Collins, director of the National Institutes of Health, showed off a replica of the virus that causes the disease. Science’s COVID-19 reporting is supported by the Pulitzer Center. The leaders of Operation […]

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Experimental COVID-19 Vaccine Shows Positive Early Results in Human Trial

BioNTech of Germany and the US pharmaceutical giant Pfizer reported positive preliminary results on Wednesday from a joint project to develop a coronavirus vaccine. Known as BNT162b1, it produces antibody responses at or above the levels seen in any […]

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How a British team discovered the first life-saving coronavirus drug

In mid-June a British research team announced that a cheap, safe, widely available drug called dexamethasone makes a huge difference in saving the lives of people severely ill with Covid-19. Perhaps no one was more surprised than the people […]

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