A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Abstract Developing therapeutics against SARS-CoV-2 could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein, but also across the full Spike (S) protein. We isolated and characterized monoclonal […]

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Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear

Abstract Korber et al. (2020) found that a SARS-CoV-2 variant in the spike protein, D614G, rapidly became dominant around the world. While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation […]

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Potential effective treatment for COVID-19: systematic review and meta-analysis of the severe infectious disease with convalescent plasma therapy

Abstract Background Convalescent plasma (CP) has been used successfully to treat many types of infectious diseases, and it has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19). However, its curative effect and feasibility have […]

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U.S. Will Pay $1.6 Billion to Novavax for Coronavirus Vaccine

Andrew Caballero-Reynolds/Agence France-Presse — Getty Images The federal government will pay the vaccine maker Novavax $1.6 billion to expedite the development of 100 million doses of a coronavirus vaccine by the beginning of next year, the company said on […]

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Few in Spanish, US studies had detectable COVID antibodies

A study published yesterday in The Lancet discovered that only 4.6% of questionnaire respondents across Spain had antibodies against SARS-CoV-2, the virus that causes COVID-19, in their serum by immunoassay, while 5% tested positive on a point-of-care finger stick […]

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US pulls out of WHO amid escalating COVID-19 activity

In rapidly evolving global COVID-19 developments today, President Donald Trump’s administration notified Congress that the United States has officially withdrawn from the World Health Organization (WHO), as the WHO announced plans to meet with China to firm up plans […]

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