Study: Baloxavir prevents spread of flu to household members

The antiviral drug baloxavir (Xofluza) prevented influenza in household contacts of infected patients, according to a study yesterday in the New England Journal of Medicine , but a US expert outlined several caveats about the findings. The multicenter randomized […]

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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Abstract Developing therapeutics against SARS-CoV-2 could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein, but also across the full Spike (S) protein. We isolated and characterized monoclonal […]

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Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear

Abstract Korber et al. (2020) found that a SARS-CoV-2 variant in the spike protein, D614G, rapidly became dominant around the world. While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation […]

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