Nasopharyngeal Microbiota Profiling of SARS-CoV-2 Infected Patients

Abstract We analyzed the bacterial communities of the nasopharynx in 40 SARS-CoV-2 infected and uninfected patients. All infected patients had a mild COVID-19 disease. We did not find statistically significant differences in either bacterial richness and diversity or composition. […]

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Development of a Multi-Antigenic SARS-CoV-2 Vaccine Using a Synthetic Poxvirus Platform

Abstract Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to develop vaccines for infectious diseases and cancer. We developed a novel vaccine platform based on a unique three-plasmid system to efficiently generate recombinant […]

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Lack of antibody-mediated cross-protection between SARS-CoV-2 and SARS-CoV infections

Abstract Background The novel coronavirus (SARS-CoV-2) shares approximately 80% whole genome sequence identity and 66% spike (S) protein identity with that of SARS-CoV. The cross-neutralization between these viruses is currently not well-defined. Methods Here, by using the live SARS-CoV-2 […]

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Current Status of Multiple Drug Molecules, and Vaccines: An Update in SARS-CoV-2 Therapeutics

The coronavirus disease of 2019 (COVID-19) is a pandemic disease that has taken the lives of many around the world. It is caused by severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2). To date, the USA, Italy, Spain, France, Russia, and […]

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Molecular architecture of the SARS-CoV-2 virus

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus responsible for the COVID-19 pandemic. Despite recent advances in the structural elucidation of SARS-CoV-2 proteins and the complexes of the spike (S) proteins with the cellular receptor […]

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In vivo structural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs

SARS-CoV-2 is an RNA virus of the Coronaviridae family that is the causal pathogen of the ongoing Coronavirus Disease 2019 pandemic. There are currently no antiviral drugs or vaccines to treat COVID-19, and the failure to identify effective interventions […]

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Few in Spanish, US studies had detectable COVID antibodies

A study published yesterday in The Lancet discovered that only 4.6% of questionnaire respondents across Spain had antibodies against SARS-CoV-2, the virus that causes COVID-19, in their serum by immunoassay, while 5% tested positive on a point-of-care finger stick […]

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This Coronavirus Doesn’t Change Quickly, And That’s Good News For Vaccine Makers

Internationally, scientists now have on file the genomes of more than 47,000 different samples of the virus that causes COVID-19 — up from just one in January. Here’s a transmission electron micrograph of SARS-CoV-2 virus particles (orange) isolated from […]

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Using the nucleocapsid protein to investigate the relationship between SARS-CoV-2 and closely related bat and pangolin coronaviruses

An initial outbreak of coronavirus disease 2019 (COVID-19) in China has resulted in a massive global pandemic causing well over 9,200,000 cases and 470,000 deaths worldwide. The virus responsible, SARS-CoV-2, is known to have a close association with Bat-CoV […]

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