COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome – ScienceDirect

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Taken together, the demonstration of ACE2 as the SARS-CoV-2 receptor for cellular entry provides a key target for therapeutic development during the initial phase of the infection. In its later phase, the potential dysregulation of the AngII-AT1R pathway downstream of ACE2 could lead to cytokine release syndrome as observed in COVID-19 patients that may require targeting of cytokine pathways, particularly IL-6-STAT3 axis.

This is a really nice short summary , well worth a read…

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