Genetic discordance of the two SARS-CoV-2 specimens was greater than could be accounted
for by short-term in vivo evolution. These findings suggest that the patient was infected
by SARS-CoV-2 on two separate occasions by a genetically distinct virus. Thus, previous
exposure to SARS-CoV-2 might not guarantee total immunity in all cases. All individuals,
whether previously diagnosed with COVID-19 or not, should take identical precautions
to avoid infection with SARS-CoV-2. The implications of reinfections could be relevant
for vaccine development and application.
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