[PDF] The SARS-CoV-2 genome: variation, implication and application | Semantic Scholar

• The most variable virus gene encodes the spike (S) protein that mediates virus attachment to and entry into cells, and is the target of neutralising antibodies and a robust T cell response. A D614G mutation in the S1 subunit of the S protein possibly enhances virus transmission and is now dominant in virus strains circulating globally. No genome changes have been identified that are shown to affect virulence. • Whole genome sequencing is a valuable addition to test, track and trace, and is encouraged. For instance it:

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