The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection

Signaling through retinoic acid inducible gene I (RIG-I) like receptors (RLRs) is tightly regulated, with activation occurring upon sensing of viral nucleic acids, and suppression mediated by negative regulators. Under homeostatic conditions aberrant activation of melanoma differentiation-associated protein-5 (MDA5) […]

Click here to view original web page at The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection

A ‘triumph of hope over facts’: The rise and fall of hydroxychloroquine for COVID-19

The rise and fall of chloroquine and hydroxychloroquine as “game-changing” treatments for COVID-19 should come as no surprise to experts who have paid attention to the history of these drugs, according to findings published in The FASEB Journal . […]

Click here to view original web page at A ‘triumph of hope over facts’: The rise and fall of hydroxychloroquine for COVID-19

How does the new coronavirus compare with the flu?

The coronavirus particle has a crown of spikes on its surface. Editor’s note: This article was revised on April 30 with the latest information on COVID-19. Since the new coronavirus was first discovered in January, many people have compared […]

Click here to view original web page at How does the new coronavirus compare with the flu?

Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: A retrospective study.

Abstract OBJECTIVES: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Umifenovir (Arbidol®) is an antiviral drug being used to treat influenza in Russia and China. This study aimed to investigate the effectiveness […]

Click here to view original web page at Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: A retrospective study.

Former FDA leaders decry emergency authorization of malaria drugs for coronavirus

After U.S. President Donald Trump advocated widespread use of two malaria drugs for COVID-19 patients, the FDA, led by Commissioner Stephen Hahn (left) produced an emergency use authorization for the medications. Science’s COVID-19 reporting is supported by the Pulitzer Center. The recent Food and Drug Administration (FDA) emergency use […]

Click here to view original web page at www.sciencemag.org

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).

Abstract PURPOSE: Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 […]

Click here to view original web page at www.ncbi.nlm.nih.gov

Here’s How COVID-19 Compares to Past Outbreaks

The 1918 flu pandemic led to hundreds of thousands of deaths in the U.S. Getty Images SARS, the 1918 flu pandemic, and Ebola have all helped public health officials prepare for major outbreaks. Each major outbreak is different though, and experts have a hard time predicting how they will […]

Click here to view original web page at www.healthline.com

Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility

The emergence of influenza viruses with reduced susceptibility to baloxavir marboxil (BXM) would limit the clinical utility of this novel antiviral. To assess the risk of such resistance emerging, we evaluated influenza A and B viruses carrying BXM-reduced susceptibility substitutions and compared their fitness to that of their drug-susceptible […]

Click here to view original web page at www.pnas.org

University researchers in Belfast have been awarded a grant to find a Covid-19 treatment

Image: Lars Hagberg via PA QUEEN’S UNIVERSITY BELFAST has been awarded a €315,000 grant in a bid to find a vaccine for coronavirus. The funding grant has been awarded as one of several projects that will receive part of a €21.5 million fund bankrolled by the UK Research and […]

Click here to view original web page at www.thejournal.ie

Respiratory and Nonrespiratory Diagnoses Associated With Influenza in Hospitalized Adults.

Abstract Importance: Seasonal influenza virus infection is a major cause of morbidity and mortality and may be associated with respiratory and nonrespiratory diagnoses. Objective: To examine the respiratory and nonrespiratory diagnoses reported for adults hospitalized with laboratory-confirmed influenza between 2010 and 2018 in the United States. Design, Setting, and […]

Click here to view original web page at www.ncbi.nlm.nih.gov