Abstract BACKGROUND: The Centers of Excellence for Influenza Research and Surveillance (CEIRS) network, funded by the US National Institutes of Health, has been operational since 2007 and is tasked with conducting research to improve understanding of influenza viruses. Recently, […]
Study Examines Wide Range of Potential Influenza-Related Complications
Vaccination and Immunization , Clinical News , Cold, Cough, and Flu , Community Practice , Health System News , Influenza , The Latest A new study highlights a broadened scope of the burden of influenza-associated complications, indicating that health care providers should be aware of a wider range of […]
Baseline Levels of Influenza-Specific B Cells and T Cell Responses Modulate Human Immune Responses to Swine Variant Influenza A/H3N2 Vaccine.
Abstract The cellular immune responses elicited by an investigational vaccine against an emergent variant of influenza (H3N2v) are not fully understood. Twenty-five subjects, enrolled in an investigational influenza A/H3N2v vaccine study, who received two doses of vaccine 21 days apart, were included in a sub-study of cellular immune responses. […]
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Symbolic transfer entropy reveals the age structure of pandemic influenza transmission from high-volume influenza-like illness data.
Abstract Existing methods to infer the relative roles of age groups in epidemic transmission can normally only accommodate a few age classes, and/or require data that are highly specific for the disease being studied. Here, symbolic transfer entropy (STE), a measure developed to identify asymmetric transfer of information between […]
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Compare: 2009 H1N1 Pandemic Versus the 2020 Coronavirus Pandemic
As everyone should know, the world is currently experiencing a global pandemic of SARS-CoV-2, the novel coronavirus that causes COVID-19. As of March 17, 2020, 194,873 people have been confirmed to have been infected with 7,869 deaths. The majority of both are in China, with 81,058 confirmed cases, which […]
Versatope Selects Influenza Vaccine Candidate for Clinical Development
Substantial Antigenic Drift in the Hemagglutinin Protein of Swine Influenza A Viruses.
Abstract The degree of antigenic drift in swine influenza A viruses (swIAV) has historically been regarded as minimal compared to that of human influenza A virus strains. However, as surveillance activities on swIAV have increased, more isolates have been characterized, revealing a high level of genetic and antigenic differences […]
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Comparison of antigenic mutation during egg and cell passage cultivation of H3N2 influenza virus.
Abstract Purpose: When influenza viruses are cultured in eggs, amino acid mutations of the hemagglutinin may occur through egg adaptation. On the other hand, when influenza viruses are cultured in animal cells, no antigenic mutation occurs unlike in eggs. Therefore, we examined whether the antigenic mutations actually occurred after […]
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Early prediction of antigenic transitions for influenza A/H3N2.
Abstract Influenza A/H3N2 is a rapidly evolving virus which experiences major antigenic transitions every two to eight years. Anticipating the timing and outcome of transitions is critical to developing effective seasonal influenza vaccines. Using a published phylodynamic model of influenza transmission, we identified indicators of future evolutionary success for […]
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