Influenza A Virus Antibodies with Antibody-Dependent Cellular Cytotoxicity Function.

Abstract Influenza causes millions of cases of hospitalizations annually and remains a public health concern on a global scale. Vaccines are developed and have proven to be the most effective countermeasures against influenza infection. Their efficacy has been largely evaluated by hemagglutinin inhibition (HI) titers exhibited by vaccine-induced neutralizing […]

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Trending News: High-Dose Influenza Vaccine More Effective for Hospitalization Prevention

Acute exacerbation of interstitial lung disease (AE-ILD) is a less frequent but fatal complication in patients with idiopathic inflammatory myopathy (IIM); however, a regimen of steroids and disease-modifying antirheumatic drugs (DMARDs) was found to reduce short-term death rates, according to The American Journal of Managed Care . Investigators from […]

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Covid-19 — Navigating the Uncharted

The latest threat to global health is the ongoing outbreak of the respiratory disease that was recently given the name Coronavirus Disease 2019 (Covid-19). Covid-19 was recognized in December 2019. 1 It was rapidly shown to be caused by a novel coronavirus that is structurally related to the virus […]

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Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA.

Abstract Influenza vaccine effectiveness varies annually due to the fast evolving seasonal influenza A(H3N2) strain and egg-derived mutations-both of which can cause a mismatch between the vaccine and circulating strains. To address these limitations, we have developed a hemagglutinin (HA)-based protein-detergent nanoparticle influenza vaccine (NIV) with a saponin-based Matrix-M™ […]

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