In vivo structural characterization of the whole SARS-CoV-2 RNA genome identifies host cell target proteins vulnerable to re-purposed drugs

SARS-CoV-2 is an RNA virus of the Coronaviridae family that is the causal pathogen of the ongoing Coronavirus Disease 2019 pandemic. There are currently no antiviral drugs or vaccines to treat COVID-19, and the failure to identify effective interventions […]

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Man, 30, Dies After Attending a ‘Covid Party,’ Texas Hospital Says

Christopher Lee for The New York Times A 30-year-old man who believed the coronavirus was a hoax and attended a “Covid party” died after being infected with the virus, according to a Texas hospital.

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COVID-19 Has Been Linked to a Rare Neurological Disorder. Here’s What We Know So Far

The patient in the case report (let’s call him Tom) was 54 and in good health. For two days in May, he felt unwell and was too weak to get out of bed. When his family finally brought him […]

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Study: Baloxavir prevents spread of flu to household members

The antiviral drug baloxavir (Xofluza) prevented influenza in household contacts of infected patients, according to a study yesterday in the New England Journal of Medicine , but a US expert outlined several caveats about the findings. The multicenter randomized […]

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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Abstract Developing therapeutics against SARS-CoV-2 could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein, but also across the full Spike (S) protein. We isolated and characterized monoclonal […]

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Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear

Abstract Korber et al. (2020) found that a SARS-CoV-2 variant in the spike protein, D614G, rapidly became dominant around the world. While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation […]

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